ABSTRACT
Context: beyond the objective outcomes of metabolic syndrome [MetS], the association between this syndrome and its patient centered outcomes need to be investigated in Middle-Eastern countries. This report aims to summarize the Tehran lipid and glucose study [TLGS] findings regarding the association between MetS and health-related quality of life [HRQoL] and its influential factors through the past decade
Evidence Acquisition: the current review has been conducted on the TLGS published data regarding different aspects of the association between MetS and HRQoL in adult participants through the last decade. To assess HRQoL, the Iranian version of short form health survey [SF-36] was used. To define MetS the most commonly used insulin resistance [IR]-and waist circumference [WC] - based MetS definitions have been applied in the publications reviewed
Results: as a whole, MetS was a determinant of poor physical HRQoL only in women [OR: 1.78; 95% CI: 1.21 - 2.61], particularly in those with more component of MetS [P < 0.001]. Results further showed that only reproductive aged women with MetS were more likely to report poor PCS compared to those without MetS even after adjusting for age [OR: 1.7, 95% CI: 1.0 - 3.0; P < 0.05]. Different structures of MetS and physical HRQoL constructs in men and women as well as age and smoking with significant gender-specific effects on mental HRQoL were factors responsible for the gender specific pattern observed. Considering the duration of MetS, only women with intermittent MetS indicated higher risk for reporting poor PCS [OR: 2.75, 95% CI: 1.19 - 6.37; P < 0.001] compared to those without MetS. The observed sex-specific pattern used to detect poor HRQoL in those with MetS was confirmed by all WC-based definitions except for the American Heart Association/National Heart, Lung, and Blood Institute [AHA/NHLBI] definition. However, none of IR-based definitions could detect poor physical and mental HRQoL in either gender
Conclusions: in summary, in the TLGS population, the association between MetS and HRQoL followed a sex specific pattern, mainly significant only in women and in the physical aspect
ABSTRACT
Inadequate folate intake could be associated with increased breast cancer risk. The aim of the present study was to assess the folate intake by designed Food Frequency Questionnaire [FFQ] using plasma folate concentration. This analytic cross-sectional study was conducted to evaluate the validity of the semi-quantitative FFQ [136 items] in 152 women with confirmed breast malignancy aged between 35 - 85 years old.. Folate plasma level was assessed by means of automated electrochemiluminescence. The Pearson and partial correlation coefficients were performed between the plasma level of folate and crude, total and energy-adjusted [residual] folate intakes. Area under ROC curve [AUC], sensitivity, specificity, positive and negative predictive values and odds ratio were fulfilled in two models in order to achieve validity assessment. The folate plasma level was significantly correlated with total intake of vegetables, bread and cereal groups [p=0.001] and also with total intake of fruits [p=0.001] and dairy products [p=0.026]. After adjusting for confounders, the folate plasma levels were correlated significantly with daily [beta=0.39], and residual [beta=0.41] folate intake levels [p=0.001]. The area under ROC curves in model I [folate plasma level <5.9 ng/ml] was 0.74 [95%CI=0.63-0.85] and for model II [folate plasma level <10.0 ng/ml] was estimated as 0.61[95%CI= 0.51- 0.71]. Model I indicated more appropriate predictive value [p=0.001] of folate intake assessment via FFQ. The results of this study showed that FFQ described in this study could be a valid and appropriate tool for assessing folate intake status in dietary content of breast cancer patients and also could be representative and valid for assessing the folate rich-food intake status